gene_symbol
UNKNOWN
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Dinutuximab beta binds GD2 on tumor cells and induces ADCC/phagocytosis and complement-dependent cytotoxicity. C1q binds the antibody Fc to activate complement but is not the antigen targeted; cells expressing C1q are not directly killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Classical complement pathway initiation; C1q complex (C1QA/C1QB/C1QC)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05558280
disease_id_num_tar_ref
3395
drug_id_num_tar_ref
9174