gene_symbol
DLL3
hgnc_id
HGNC:2909
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Tarlatamab bridges CD3+ T cells to DLL3-expressing cells, forming an immune synapse and activating CTLs to kill target cells via perforin/granzyme-mediated cytolysis and apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
tumor-associated surface antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06598306
disease_id_num_tar_ref
3403
drug_id_num_tar_ref
9188