gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Tarlatamab binds CD3 on T cells to recruit and activate them against DLL3-expressing tumor cells; the T cells then kill DLL3+ targets via perforin/granzyme after immune synapse formation, not the CD3+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell receptor CD3 complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06598306
disease_id_num_tar_ref
3403
drug_id_num_tar_ref
9188