gene_symbol
GPRC5D
hgnc_id
HGNC:13310
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Talquetamab links CD3 on T cells to GPRC5D on target cells, triggering T‑cell activation and perforin/granzyme‑mediated lysis of GPRC5D‑expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-associated antigen on malignant plasma cells; off-tumor expression in keratinized/oral tissues
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06500884
disease_id_num_tar_ref
3409
drug_id_num_tar_ref
9199