gene_symbol
IL2RB
hgnc_id
HGNC:6009
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
IL-2 receptor beta mediates IL-15 signaling to support the engineered NK cells; it is not targeted for killing. The drug kills CD19-positive cells via CAR-mediated NK cytotoxicity (perforin/granzyme and death receptor pathways).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IL-15 engages IL2RB as part of the signaling complex to promote NK activation/persistence
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06707259
disease_id_num_tar_ref
1
drug_id_num_tar_ref
1