gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds HER2, is internalized, and releases the DXd topoisomerase I inhibitor after lysosomal cleavage, causing DNA damage and apoptosis; Fc can also trigger ADCC. Bystander killing may occur via diffusible payload.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Antibody component (trastuzumab) binds extracellular HER2 to enable internalization and ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06663787
disease_id_num_tar_ref
3414
drug_id_num_tar_ref
9218