gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Antibody binds Claudin18.2 and engages Fc-mediated effector functions—NK cell ADCC, complement-dependent cytotoxicity (CDC), and likely macrophage ADCP—to kill target-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Selective for CLDN18 isoform 2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05608785
disease_id_num_tar_ref
3415
drug_id_num_tar_ref
9222