gene_symbol
CD274
hgnc_id
HGNC:17635
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-engineered NK-92 cells bind PD-L1 on target cells and directly lyse them via NK cytotoxic pathways (perforin/granzyme); high-affinity CD16 also enables ADCC when antibodies are present.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CAR-mediated recognition on tumor and immunosuppressive myeloid cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06061809
disease_id_num_tar_ref
3422
drug_id_num_tar_ref
9246