gene_symbol
IGHG1
hgnc_id
HGNC:5525
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Killing occurs via ADCC: the NK-92 cells’ high‑affinity CD16 binds the IgG1 Fc of therapeutic antibodies opsonizing target cells, triggering NK degranulation and lysis. The IgG1 Fc region itself is not a cellular antigen directly targeted.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Ligand for high-affinity CD16 (FcγRIIIa V158) enabling ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06061809
disease_id_num_tar_ref
3422
drug_id_num_tar_ref
9246