gene_symbol
IL5RA
hgnc_id
HGNC:6017
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Rα on eosinophils/basophils and, via its afucosylated Fc, strongly engages FcγRIIIa on NK cells to trigger ADCC (perforin/granzyme-mediated killing), depleting IL-5Rα+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor on eosinophils/basophils; Fab-mediated binding blocks IL-5 signaling and enables ADCC of IL5RA+ cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06501807
disease_id_num_tar_ref
3427
drug_id_num_tar_ref
9259