gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2, is internalized, and releases a DXd topoisomerase I inhibitor that causes DNA damage and apoptosis; Fc can also trigger ADCC, with a membrane-permeable payload enabling bystander killing.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antibody component (trastuzumab) binds extracellular domain of HER2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05744375
disease_id_num_tar_ref
3430
drug_id_num_tar_ref
9268