gene_symbol
CD33
hgnc_id
HGNC:1659
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds CD33 on target cells, is internalized, and releases calicheamicin, which induces DNA double‑strand breaks leading to apoptosis of the CD33+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Sialic acid-binding Ig-like lectin (SIGLEC3); internalizes to deliver calicheamicin
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05199051
disease_id_num_tar_ref
3432
drug_id_num_tar_ref
9277