gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
GS-5423 binds HIV-1 Env on infected cells; its Fc engages CD16a on NK cells/macrophages to trigger ADCC/ADCP against Env+ cells. CD16a+ effector cells are not targeted or killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IgG1 Fc engagement mediating ADCC on NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06071767
disease_id_num_tar_ref
3438
drug_id_num_tar_ref
9294