gene_symbol
FCGR2A
hgnc_id
HGNC:3616
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
GS-5423 binds HIV-1 Env on infected cells; its Fc engages FcγRIIa (CD32a) on myeloid effector cells to trigger ADCP/ADCC (±CDC) that kills Env+ targets, not the CD32a-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IgG1 Fc engagement mediating ADCP on monocytes/macrophages
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06071767
disease_id_num_tar_ref
3438
drug_id_num_tar_ref
9294