gene_symbol
PSCA
hgnc_id
HGNC:9500
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells bind PSCA on target cells and, via CD3ζ activation with 4-1BB co-stimulation, directly kill PSCA-positive cells through perforin/granzyme (and Fas–FasL) cytotoxicity.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05805371
disease_id_num_tar_ref
3447
drug_id_num_tar_ref
9329