gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The drug targets HER2 on tumor cells and blocks CD47–SIRPα to permit macrophage-mediated phagocytosis and downstream T-cell responses. CD47 expression alone is not sufficient; HER2+ cells are eliminated via immune-mediated killing, not by direct cytotoxic action on CD47.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
Bispecific arm that blocks CD47–SIRPα; CD47 engagement is preferential when co-bound to HER2 (cis-avid gating).
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05957536
disease_id_num_tar_ref
3450
drug_id_num_tar_ref
9334