gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The bispecific antibody binds HER2 on tumor cells and blocks CD47–SIRPα, removing the “don’t‑eat‑me” signal and enabling macrophage-mediated phagocytosis (and Fc-driven ADCP), leading to killing of HER2+ cells; T‑cell responses are secondary.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-associated antigen engagement that localizes/anchors the bispecific and facilitates cis-avid CD47 blockade.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05957536
disease_id_num_tar_ref
3450
drug_id_num_tar_ref
9334