gene_symbol
GPRC5D
hgnc_id
HGNC:13310
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells recognize GPRC5D on target cells and, upon CAR activation, kill them via perforin/granzyme-mediated cytolysis (and death-receptor signaling).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor on malignant plasma cells; part of dual-target CAR where either-antigen engagement activates T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06068400
disease_id_num_tar_ref
3454
drug_id_num_tar_ref
9349