gene_symbol
VTCN1
hgnc_id
HGNC:28873
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds B7-H4 on target cells, is internalized, and releases a cytotoxic payload intracellularly, inducing apoptosis of B7-H4–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Also known as B7x/B7S1; cell-surface immune checkpoint ligand; ADC binding triggers internalization.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06233942
disease_id_num_tar_ref
291
drug_id_num_tar_ref
822