gene_symbol
BCL2
hgnc_id
HGNC:990
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Venetoclax inhibits anti-apoptotic BCL-2, triggering mitochondrial outer membrane permeabilization, cytochrome c release, and caspase activation to induce intrinsic apoptosis in BCL-2-dependent cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
BH3-mimetic binding to the hydrophobic groove; selective for BCL-2 and spares BCL-XL
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06496308
disease_id_num_tar_ref
3464
drug_id_num_tar_ref
9376