gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Blinatumomab binds CD3 on T cells to recruit them to CD19+ cells, leading to perforin/granzyme-mediated lysis of the CD19+ targets; CD3+ T cells are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
epsilon chain of CD3 complex on T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06438796
disease_id_num_tar_ref
3472
drug_id_num_tar_ref
9403