gene_symbol
CDH3
hgnc_id
HGNC:1762
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
AMG 305 is a T‑cell–engaging bispecific that links CD3 on T cells to CDH3 and MSLN on tumor cells, activating T cells to kill dual‑positive cells via perforin/granzyme‑mediated cytolysis; CDH3-only cells are largely spared.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
Tumor-associated antigen; activity requires co-engagement with mesothelin on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05800964
disease_id_num_tar_ref
3475
drug_id_num_tar_ref
9409