gene_symbol
MSLN
hgnc_id
HGNC:7371
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
AMG 305 crosslinks CD3 on T cells to mesothelin and CDH3 on tumor cells, activating T-cell cytotoxicity (perforin/granzyme) to lyse cells co-expressing mesothelin and CDH3.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
Tumor-associated antigen; activity requires co-engagement with cadherin-3 on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05800964
disease_id_num_tar_ref
3475
drug_id_num_tar_ref
9409