gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD3 is on T cells; AMG 305 binds CD3 to recruit and activate T cells, which then kill CDH3/MSLN dual-positive tumor cells via perforin/granzyme-mediated cytolysis. CD3+ cells themselves are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell engager/activation arm on cytotoxic T lymphocytes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05800964
disease_id_num_tar_ref
3475
drug_id_num_tar_ref
9409