gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets DLK-1 for binding and internalization; released MMAE then inhibits tubulin polymerization to cause G2/M arrest and apoptosis, with possible bystander killing of nearby cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cytotoxic payload (MMAE) target; inhibition of polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06005740
disease_id_num_tar_ref
3481
drug_id_num_tar_ref
9429