gene_symbol
MICA
hgnc_id
HGNC:7090
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered gamma-delta T cells expressing an NKG2D-based CAR bind MICA on target cells, activating MHC-independent cytotoxicity via perforin/granzyme-mediated lysis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
NKG2D ligand; stress-induced; bound by NKG2D CAR ectodomain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05302037
disease_id_num_tar_ref
3490
drug_id_num_tar_ref
9448