gene_symbol
ULBP2
hgnc_id
HGNC:14894
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
NKG2D-CAR–engineered gamma-delta T cells bind ULBP2 on target cells, triggering T-cell activation and MHC-independent cytolysis via perforin/granzyme release (and related cytotoxic pathways).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
NKG2D ligand; stress-induced; bound by NKG2D CAR ectodomain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05302037
disease_id_num_tar_ref
3490
drug_id_num_tar_ref
9448