gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab’s IgG1 Fc engages Fcγ receptors on immune effector cells (e.g., NK cells, macrophages) to induce ADCC (and potentially CDC), killing EGFR-expressing cells; EGFR blockade itself is primarily antiproliferative.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain (ECD); blocks ligand binding and receptor dimerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05743036
disease_id_num_tar_ref
3509
drug_id_num_tar_ref
9510