gene_symbol
LGR5
hgnc_id
HGNC:4504
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
LGR5-specific CAR T cells bind LGR5 on target cells, become activated, and kill LGR5-positive cells via T-cell cytotoxic pathways (perforin/granzyme release and Fas/FasL-mediated apoptosis).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface receptor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05759728
disease_id_num_tar_ref
3521
drug_id_num_tar_ref
9540