gene_symbol
FOLH1
hgnc_id
HGNC:3788
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
PSMA-targeted 177Lu radioligand binds and is internalized by PSMA-expressing cells, emitting beta particles that cause DNA double‑strand breaks leading to cell death (with crossfire to nearby cells).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Small-molecule PSMA ligand chelating 177Lu; internalization delivers beta radiation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06199453
disease_id_num_tar_ref
296
drug_id_num_tar_ref
842