gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
LCAR-M61D CAR T cells are engineered to recognize myeloma-associated antigens (not CD19); therefore CD19+ cells are not targeted. When the CAR binds its cognate antigen, killing occurs via T-cell perforin/granzyme-mediated cytotoxicity.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Inferred from trial exclusion of prior CD19-directed therapy; CAR-T likely targets CD19.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06472479
disease_id_num_tar_ref
25
drug_id_num_tar_ref
64