gene_symbol
LAIR1
hgnc_id
HGNC:6477
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti–LAIR-1 IgG1 binds LAIR-1 on target cells and engages FcγR-expressing effectors to mediate ADCC (NK cells) and ADCP (macrophages); blockade of LAIR-1 inhibitory signaling also reduces survival of LAIR-1–positive AML blasts/LSCs.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Inhibitory immune checkpoint receptor; antagonistic blockade
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05787496
disease_id_num_tar_ref
3547
drug_id_num_tar_ref
9616