gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
HB-201 is a therapeutic vaccine that primes HPV16 E6/E7–specific CD8+ T cells; these CTLs recognize E6-derived peptides on MHC I of HPV16+ tumor cells and kill them via perforin/granzyme and Fas/FasL pathways.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
HPV16-specific viral antigen; peptides presented on MHC class I of tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05108870
disease_id_num_tar_ref
3555
drug_id_num_tar_ref
9642