gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Engineered NK cells kill only cells presenting PRAME peptide in HLA-A*02:01 via TCR engagement, triggering perforin/granzyme-mediated lysis; HLA-A*02:01 alone is not sufficient.
enzyme_product
Off
epitope
Off
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Allele restriction component of the PRAME peptide–HLA complex required for TCR binding.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06383572
disease_id_num_tar_ref
297
drug_id_num_tar_ref
843