gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
RC48-ADC targets HER2, not β-tubulin. After HER2-mediated internalization, MMAE is released and inhibits β-tubulin to block microtubule polymerization, causing G2/M arrest and apoptosis; Fc-mediated ADCC and bystander effects may contribute.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Vinca-binding site target of MMAE payload; inhibits tubulin polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05996952
disease_id_num_tar_ref
3561
drug_id_num_tar_ref
9663