gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 on target cells and its Fc engages Fcγ receptors on effector cells (e.g., NK cells), triggering ADCC and lysis of HER2-positive cells.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain subdomain IV of HER2; binding can inhibit HER2 signaling and enable ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06681298
disease_id_num_tar_ref
3564
drug_id_num_tar_ref
9669