gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD38 IgG1 mAb binds CD38 on target cells and triggers Fc-mediated ADCC (NK cells), ADCP (macrophages), complement-dependent cytotoxicity (CDC), and can induce direct apoptosis upon binding/crosslinking.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface type II transmembrane glycoprotein; ectoenzyme (ADP-ribosyl cyclase/cADPR hydrolase)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06297681
disease_id_num_tar_ref
300
drug_id_num_tar_ref
854