gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 on tumor cells and its Fc engages Fc gamma receptors on immune effectors (e.g., NK cells, macrophages) to mediate antibody-dependent cellular cytotoxicity and phagocytosis, killing HER2+ cells; it also inhibits HER2 signaling.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain IV of HER2; IgG1 Fc can engage Fcγ receptors to mediate ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06109467
disease_id_num_tar_ref
3575
drug_id_num_tar_ref
9693