gene_symbol
CD274
hgnc_id
HGNC:17635
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 Fc recruits NK cells via Fc gamma receptors to mediate ADCC against PD-L1–expressing cells; checkpoint blockade also restores CTL killing (indirect).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks interaction with PD-1 (PDCD1) and CD80 (B7-1)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04188119
disease_id_num_tar_ref
3583
drug_id_num_tar_ref
9715