gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Avelumab engages CD16A (FcγRIIIA) on NK cells via its Fc to trigger ADCC against PD-L1–expressing targets; CD16A+ cells are effectors, not targets, and are not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated engagement on NK cells to induce ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04188119
disease_id_num_tar_ref
3583
drug_id_num_tar_ref
9715