gene_symbol
CTLA4
hgnc_id
HGNC:2505
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Antibody binds CTLA-4 on Tregs and its engineered Fc engages FcγR-bearing effectors (NK cells/macrophages), inducing ADCC/antibody-dependent phagocytosis (and possibly CDC) to deplete CTLA-4–high intratumoral Tregs.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CD152; immune checkpoint receptor on T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05632328
disease_id_num_tar_ref
301
drug_id_num_tar_ref
859