gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Epcoritamab engages CD3ε on T cells and CD20 on B cells to form an immune synapse, activating T cells to kill CD20+ B cells via perforin/granzyme cytolysis; CD3ε+ T cells are not killed.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
TCR-CD3 complex subunit
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05848765
disease_id_num_tar_ref
3590
drug_id_num_tar_ref
9746