gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells and induces strong direct, caspase-independent cell death (type II) and engages Fc gamma RIIIa on NK cells/macrophages to mediate ADCC; CDC is limited.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II anti-CD20 monoclonal antibody; glycoengineered Fc enhances FcgammaRIIIa-mediated ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05848765
disease_id_num_tar_ref
3590
drug_id_num_tar_ref
9749