gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
HER2+ cells are opsonized by trastuzumab and killed via Fc-mediated ADCC by NK cells (and other FcγR+ effectors); complement may contribute. Signaling blockade is antiproliferative rather than cytotoxic.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (subdomain IV) of HER2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06504732
disease_id_num_tar_ref
3594
drug_id_num_tar_ref
9769