gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Antigen-specific CTLs recognize the tumor peptide presented by HLA-A via their TCR and kill the presenting cells through perforin/granzyme-mediated cytolysis and death-receptor (FasL/TRAIL)–induced apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–MHC complex recognized by endogenous TCR; patient- and antigen-specific; may include neoantigens
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06296056
disease_id_num_tar_ref
302
drug_id_num_tar_ref
863