gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Rα on eosinophils/basophils; its afucosylated Fc engages FcγRIIIa (CD16a) on NK cells to trigger ADCC that kills IL-5Rα+ cells. FcγRIIIa-expressing cells are effectors, not targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated engagement on NK cells enabling antibody-dependent cell-mediated cytotoxicity; affinity enhanced by afucosylation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06163807
disease_id_num_tar_ref
3601
drug_id_num_tar_ref
9788