gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab coats EGFR-expressing cells and its IgG1 Fc engages Fcγ receptors on effector cells (e.g., NK cells) to trigger ADCC (and some CDC), leading to target-cell lysis; EGFR blockade is mainly antiproliferative.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (domain III); blocks ligand binding and receptor dimerization; IgG1 Fc can mediate ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06322147
disease_id_num_tar_ref
3608
drug_id_num_tar_ref
9801