gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds EGFR on tumor cells, is internalized, and releases a topoisomerase I inhibitor (gitecan) payload that induces DNA damage, killing EGFR-expressing cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
HER1/ErbB1; receptor tyrosine kinase targeted by the bispecific ADC antibody
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06437509
disease_id_num_tar_ref
3610
drug_id_num_tar_ref
9809