gene_symbol
CD70
hgnc_id
HGNC:11937
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells recognize CD70 via the CAR, become activated (CD3ζ/costimulatory signaling), and kill CD70+ cells through perforin/granzyme release and death-receptor (Fas/TRAIL)–mediated apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
TNF ligand family member; ligand for CD27
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05990621
disease_id_num_tar_ref
3611
drug_id_num_tar_ref
9811