gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Belantamab mafodotin targets BCMA on plasma cells, is internalized, and releases MMAF that binds beta‑tubulin to block microtubule polymerization, causing G2/M arrest and apoptosis; afucosylated Fc also promotes ADCC/ADCP. Tubulin expression alone is not sufficient for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC payload (MMAF) target; inhibits microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05145816
disease_id_num_tar_ref
3612
drug_id_num_tar_ref
9814